XLP

XLP
(= X-linked lymphoproliferative disease.)
The X-linked lymphoproliferative disease (XLP), one of six described X-linked immunodeficiencies, stems from a mutation at Xq25 which renders males impotent to mount an effective immune response to the ubiquitous EBV. Proliferation of EBV-infected B-cells is apparently unregulated and invariably results in fatal mononucleosis, agammaglobulinemia, or malignant lymphoma. See SAP.

Dictionary of molecular biology. 2004.

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  • X-linked lymphoproliferative syndrome — (XLP syndrome, Duncan s disease) a hereditary disorder of the immune system caused by a defective sex linked gene carried on an X chromosome. There is uncontrolled proliferation of B lymphocyte in response to infection by the Epstein Barr virus,… …   Medical dictionary

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  • Proteine inhibitrice de l’apoptose liee au chromosome X — Protéine inhibitrice de l’apoptose liée au chromosome X La protéine inhibitrice de l’apoptose liée au chromosome X (XIAP) fait partie de la famille des protéines inhibitrices de l’apoptose (IAPs)(1). XIAP a été identifié par Duckett et al. en… …   Wikipédia en Français

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